Blog Archives

Disrupted neural activity patterns to novelty and effort in young adult APOE-e4 carriers performing a subsequent memory task

Introduction The APOE e4 allele has been linked to poorer cognitive aging and enhanced dementia risk. Previous imaging studies have used subsequent memory paradigms to probe hippocampal function in e4 carriers across the age range, and evidence suggests a pattern

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Doing a PhD in the Alzheimer’s Society Doctoral Training Centre at Sussex –being part of a team and enjoying it!

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The Elusive Nature of APOE ε4 in Mid-adulthood: Understanding the Cognitive Profile

Objectives: The apolipoprotein E (APOE) ε4 allele is an established risk factor for dementia, yet this genetic variant is associated with a mixed cognitive profile across the lifespan. This study undertakes both a systematic and meta-analytic review of research investigating APOE-related differences

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Posted in Publications, Research

5 Tips from a Thesis Writing Boot Camp

Right before the holiday season, I decided to attend the Sussex University Doctoral School’s Thesis Boot Camp and was pleasantly surprised by how much I accomplished and learned. One limitation was that the writing workshops mostly catered to the humanities

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Posted in Lab Life

Dementia in the clinic

One of my PhD colleagues, Rebecca Atkinson, wrote recently that each student at Sussex funded by the Alzheimer’s Society charity is afforded the opportunity to complete placements in a local Memory Assessment Services (MAS) clinic. I was paired with Consultant

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Posted in Lab Life

The APOE paradox: do attentional control differences in mid-adulthood reflect risk of late-life cognitive decline

Possession of an APOE e4 allele is an established risk factor for Alzheimer’s disease, while the less commonly studied e2 variant is premised to offer some protection. This research explores the purported deleterious-protective dichotomy of APOE variants on attentional control in mid-adulthood. 66 volunteers,

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Posted in Publications, Research

A clinical perspective: visiting the Memory Assessment Services (II)

In the past months I had the opportunity to shadow Dr. Klugman during two Memory Assessment sessions at the Hill Rise memory clinic in Newhaven. During my short visits there I had the chance to learn more about the process

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Posted in Lab Life, Uncategorized

A clinical perspective: visiting the Memory Assessment Services

As a PhD student, the funding for my studentship comes from the Alzheimer’s Society. This is part of an Alzheimer’s Society Doctoral Training Centre at the University of Sussex, which supports the research of eight PhD students from multiple disciplines

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Posted in Lab Life, Uncategorized

How do genetic risk factors for dementia influence cognition earlier in the lifespan?

We all age, but why do some of us age better than others? This question is especially poignant for the field of cognitive ageing, with the prevalence of dementia rising each year. At the University of Sussex, the Ageing &

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APOE Symposium

On May 10th, Sussex Doctoral School hosted a symposium recognising the role of Apolipoprotein (APOE) in the development and progression of Alzheimer’s disease. Carrying an APOE e4 gene is established to increase the risk of Alzheimer’s disease in older adulthood, as well as

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Posted in Events, Lab Life, News, Uncategorized