Blog Archives

The Elusive Nature of APOE ε4 in Mid-adulthood: Understanding the Cognitive Profile

Objectives: The apolipoprotein E (APOE) ε4 allele is an established risk factor for dementia, yet this genetic variant is associated with a mixed cognitive profile across the lifespan. This study undertakes both a systematic and meta-analytic review of research investigating APOE-related differences

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Posted in Publications, Research

The APOE paradox: do attentional control differences in mid-adulthood reflect risk of late-life cognitive decline

Possession of an APOE e4 allele is an established risk factor for Alzheimer’s disease, while the less commonly studied e2 variant is premised to offer some protection. This research explores the purported deleterious-protective dichotomy of APOE variants on attentional control in mid-adulthood. 66 volunteers,

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Posted in Publications, Research

Advances in Hepatitis C research: associated neurocognitive symptoms

Hepatitis C virus (HCV) is a major health burden in England (Public Health England, 2015). HCV treatment is a significant component in control of the disease but the neuropsychiatric side effects of the treatment have been associated with treatment interruption.

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Posted in Research, Uncategorized

Alzheimer’s Research UK 2016 Conference – II

Day 1 The themes of the 1st day of the main AD conference were Frontotemporal dementia, Neurovascular dysfunction, and Inflammation & Immunity. One of many fascinating presentations on this was given by Jessica Duncombe, a 3rd year PhD student from

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Posted in Events, News, Research, Uncategorized

Ageing Speciality Research Group Meeting

Four members of the lab group attended the regional meeting of the National Institute for Health Research this week. Talks covered a wide range of topics including the importance of involving patients and the general public in the design of clinical

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Posted in Events, Lab Life, News, Research

HCV Treatment in HIV HCV co infection population

Research in the Rusted Lab includes a study of the potential adverse side effects of hepatitis C treatment in HIV-positive individuals with a concurrent Hepatitis C infection – this is a condition that affects 40% of HIV patients. In these

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Posted in Research

Understanding risk factors for dementia across the lifespan

It is inevitable that we all show a slight decline in our cognitive abilities with increasing age, but what causes some of us to ‘drop-off’ to a greater degree than others? This question is a key focus of the Rusted

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Posted in Research

Encouraging Children to Act Out!

In addition to aging and dementia, the Rusted Lab is curious about the development of children and how it compares to the aging process later on in life. Molly Berenhaus, a second year PhD student and devoted member of the

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Posted in Research