Blog Archives

The Elusive Nature of APOE ε4 in Mid-adulthood: Understanding the Cognitive Profile

Objectives: The apolipoprotein E (APOE) ε4 allele is an established risk factor for dementia, yet this genetic variant is associated with a mixed cognitive profile across the lifespan. This study undertakes both a systematic and meta-analytic review of research investigating APOE-related differences

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Posted in Publications, Research

Dementia in the clinic

One of my PhD colleagues, Rebecca Atkinson, wrote recently that each student at Sussex funded by the Alzheimer’s Society charity is afforded the opportunity to complete placements in a local Memory Assessment Services (MAS) clinic. I was paired with Consultant

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Posted in Lab Life

The APOE paradox: do attentional control differences in mid-adulthood reflect risk of late-life cognitive decline

Possession of an APOE e4 allele is an established risk factor for Alzheimer’s disease, while the less commonly studied e2 variant is premised to offer some protection. This research explores the purported deleterious-protective dichotomy of APOE variants on attentional control in mid-adulthood. 66 volunteers,

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Posted in Publications, Research

Ageing Speciality Research Group Meeting

Four members of the lab group attended the regional meeting of the National Institute for Health Research this week. Talks covered a wide range of topics including the importance of involving patients and the general public in the design of clinical

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Posted in Events, Lab Life, News, Research

Understanding risk factors for dementia across the lifespan

It is inevitable that we all show a slight decline in our cognitive abilities with increasing age, but what causes some of us to ‘drop-off’ to a greater degree than others? This question is a key focus of the Rusted

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Posted in Research