{"id":264,"date":"2016-08-31T13:00:54","date_gmt":"2016-08-31T13:00:54","guid":{"rendered":"http:\/\/blogs.sussex.ac.uk\/jrustedlab\/?p=264"},"modified":"2016-08-31T13:02:11","modified_gmt":"2016-08-31T13:02:11","slug":"the-apoe-paradox-do-attentional-control-differences-in-mid-adulthood-reflect-risk-of-late-life-cognitive-decline","status":"publish","type":"post","link":"https:\/\/blogs.sussex.ac.uk\/jrustedlab\/2016\/08\/31\/the-apoe-paradox-do-attentional-control-differences-in-mid-adulthood-reflect-risk-of-late-life-cognitive-decline\/","title":{"rendered":"The APOE paradox: do attentional control differences in mid-adulthood reflect risk of late-life cognitive decline"},"content":{"rendered":"<p>Possession of an\u00a0<em>APOE<\/em>\u00a0e4 allele is an established risk factor for Alzheimer\u2019s disease, while the less commonly studied e2 variant is premised to offer some protection. This research explores the purported deleterious-protective dichotomy of\u00a0<em>APOE<\/em>\u00a0variants on attentional control in mid-adulthood. 66 volunteers, aged 45-55 years, completed three tasks that provided complementary measures of attentional control: prospective memory, sustained attention and inhibition. Performance was compared between e2 carriers, e4 carriers and e3 homozygotes (the population norm). Carriers of the e4 allele showed subtle disadvantages, compared to the e3 group, in accuracy of Stroop task and prospective memory performance. Contrary to expectations, e2 carriers showed performance disadvantages in sustained attention. The finding of detrimental effects in attentional control for both e4 and e2 complicates the current model that proposes opposing effects of these variants on later-life cognition. Future research is needed to understand how cognitive differences develop with increasing age, and the physiological mechanisms that underpin these changes.<\/p>\n<p><a href=\"http:\/\/authors.elsevier.com\/sd\/article\/S0197458016301932\" target=\"_blank\">For full online-access to the article click here<\/a><\/p>\n<table>\n<tbody>\n<tr>\n<th>Title<\/th>\n<td>\n<div class=\"content-wrapper\">The APOE paradox: how do attentional control differences in mid-adulthood reflect risk of late-life cognitive decline<\/div>\n<\/td>\n<\/tr>\n<tr>\n<th>Published in<\/th>\n<td>\n<div class=\"content-wrapper\">Neurobiology of Aging<\/div>\n<\/td>\n<\/tr>\n<tr>\n<th>DOI<\/th>\n<td><a href=\"http:\/\/dx.doi.org\/10.1016\/j.neurobiolaging.2016.08.015\" target=\"_blank\">10.1016\/j.neurobiolaging.2016.08.015<\/a><\/td>\n<\/tr>\n<tr>\n<th>Authors<\/th>\n<td>\n<div class=\"content-wrapper\">\n<p class=\"truncated\">Claire Lancaster, Naji Tabet, Jennifer Rusted<\/p>\n<\/div>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>Possession of an\u00a0APOE\u00a0e4 allele is an established risk factor for Alzheimer\u2019s disease, while the less commonly studied e2 variant is premised to offer some protection. This research explores the purported deleterious-protective dichotomy of\u00a0APOE\u00a0variants on attentional control in mid-adulthood. 66 volunteers,<span class=\"ellipsis\">&hellip;<\/span><\/p>\n<div class=\"read-more\"><a href=\"https:\/\/blogs.sussex.ac.uk\/jrustedlab\/2016\/08\/31\/the-apoe-paradox-do-attentional-control-differences-in-mid-adulthood-reflect-risk-of-late-life-cognitive-decline\/\">Read more &#8250;<\/a><\/div>\n<p><!-- end of .read-more --><\/p>\n","protected":false},"author":140,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"spay_email":"","jetpack_publicize_message":"","jetpack_is_tweetstorm":false},"categories":[98536,24],"tags":[90767,90572,93294,97103,91187,92913,90890,94163,97112,90342,97085,39476,83973,59977],"jetpack_featured_media_url":"","jetpack_publicize_connections":[],"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5XslT-4g","_links":{"self":[{"href":"https:\/\/blogs.sussex.ac.uk\/jrustedlab\/wp-json\/wp\/v2\/posts\/264"}],"collection":[{"href":"https:\/\/blogs.sussex.ac.uk\/jrustedlab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.sussex.ac.uk\/jrustedlab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.sussex.ac.uk\/jrustedlab\/wp-json\/wp\/v2\/users\/140"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.sussex.ac.uk\/jrustedlab\/wp-json\/wp\/v2\/comments?post=264"}],"version-history":[{"count":7,"href":"https:\/\/blogs.sussex.ac.uk\/jrustedlab\/wp-json\/wp\/v2\/posts\/264\/revisions"}],"predecessor-version":[{"id":271,"href":"https:\/\/blogs.sussex.ac.uk\/jrustedlab\/wp-json\/wp\/v2\/posts\/264\/revisions\/271"}],"wp:attachment":[{"href":"https:\/\/blogs.sussex.ac.uk\/jrustedlab\/wp-json\/wp\/v2\/media?parent=264"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.sussex.ac.uk\/jrustedlab\/wp-json\/wp\/v2\/categories?post=264"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.sussex.ac.uk\/jrustedlab\/wp-json\/wp\/v2\/tags?post=264"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}