{"id":285,"date":"2017-01-18T10:10:44","date_gmt":"2017-01-18T10:10:44","guid":{"rendered":"https:\/\/blogs.sussex.ac.uk\/jrustedlab\/?p=285"},"modified":"2017-01-18T10:10:44","modified_gmt":"2017-01-18T10:10:44","slug":"the-elusive-nature-of-apoe-%ce%b54-in-mid-adulthood-understanding-the-cognitive-profile","status":"publish","type":"post","link":"https:\/\/blogs.sussex.ac.uk\/jrustedlab\/2017\/01\/18\/the-elusive-nature-of-apoe-%ce%b54-in-mid-adulthood-understanding-the-cognitive-profile\/","title":{"rendered":"The Elusive Nature of APOE \u03b54 in Mid-adulthood: Understanding the Cognitive Profile"},"content":{"rendered":"<p><strong><span class=\"bold\">Objectives:<\/span><\/strong>\u00a0The apolipoprotein E (<span class=\"italic\">APOE<\/span>) \u03b54 allele is an established risk factor for dementia, yet this genetic variant is associated with a mixed cognitive profile across the lifespan. This study undertakes both a systematic and meta-analytic review of research investigating\u00a0<span class=\"italic\">APOE-<\/span>related differences in cognition in mid-adulthood, when detrimental effects of the allele may first be detectable.<\/p>\n<p><strong><span class=\"bold\">Methods:<\/span><\/strong>\u00a0Thirty-six papers investigating the behavioral effects of\u00a0<span class=\"italic\">APOE<\/span>\u00a0\u03b54 in mid-adulthood (defined as a mean sample age between 35 and 60 years) were reviewed. In addition, the effect of carrying an \u03b54 allele on individual cognitive domains was assessed in separate meta-analyses.<\/p>\n<p><strong><span class=\"bold\">Results:<\/span><\/strong>\u00a0The average effect size of\u00a0<span class=\"italic\">APOE<\/span>\u00a0\u03b54 status was non-significant across cognitive domains. Further consideration of genotype effects indicates preclinical effects of\u00a0<span class=\"italic\">APOE<\/span>\u00a0\u03b54 may be observable in memory and executive functioning.<\/p>\n<p><strong><span class=\"bold\">Conclusions:<\/span><\/strong>\u00a0The cognitive profile of\u00a0<span class=\"italic\">APOE<\/span>\u00a0\u03b54 carriers at mid-age remains elusive. Although there is support for comparable performance by \u03b54 and non-e4 carriers in the 5<span class=\"sup\">th<\/span>\u00a0decade, studies administering sensitive cognitive paradigms indicate a more nuanced profile of cognitive differences. Methodological issues in this field preclude strong conclusions, which future research must address, as well as considering the influence of further vulnerability factors on genotype effects.<\/p>\n<p style=\"text-align: right\">\n<p>Lancaster, C., Tabet, N., &amp; Rusted, J. (2016). The Elusive Nature of APOE \u03b54 in Mid-adulthood: Understanding the Cognitive Profile.\u00a0<i>Journal of the International Neuropsychological Society<\/i>, 1-15.<\/p>\n<p><a href=\"https:\/\/www.cambridge.org\/core\/journals\/journal-of-the-international-neuropsychological-society\/article\/div-classtitlethe-elusive-nature-of-span-classitalicapoespan-4-in-mid-adulthood-understanding-the-cognitive-profilediv\/5B64B03C45B86E05A5CAB53646057E0A\/core-reader\" target=\"_blank\">For full online access to the article click here<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Objectives:\u00a0The apolipoprotein E (APOE) \u03b54 allele is an established risk factor for dementia, yet this genetic variant is associated with a mixed cognitive profile across the lifespan. This study undertakes both a systematic and meta-analytic review of research investigating\u00a0APOE-related differences<span class=\"ellipsis\">&hellip;<\/span><\/p>\n<div class=\"read-more\"><a href=\"https:\/\/blogs.sussex.ac.uk\/jrustedlab\/2017\/01\/18\/the-elusive-nature-of-apoe-%ce%b54-in-mid-adulthood-understanding-the-cognitive-profile\/\">Read more &#8250;<\/a><\/div>\n<p><!-- end of .read-more --><\/p>\n","protected":false},"author":140,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"spay_email":"","jetpack_publicize_message":"","jetpack_is_tweetstorm":false},"categories":[98536,24],"tags":[97119,97103,92913,97122,97120,90342,98536,97121,39476,59977],"jetpack_featured_media_url":"","jetpack_publicize_connections":[],"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5XslT-4B","_links":{"self":[{"href":"https:\/\/blogs.sussex.ac.uk\/jrustedlab\/wp-json\/wp\/v2\/posts\/285"}],"collection":[{"href":"https:\/\/blogs.sussex.ac.uk\/jrustedlab\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.sussex.ac.uk\/jrustedlab\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.sussex.ac.uk\/jrustedlab\/wp-json\/wp\/v2\/users\/140"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.sussex.ac.uk\/jrustedlab\/wp-json\/wp\/v2\/comments?post=285"}],"version-history":[{"count":9,"href":"https:\/\/blogs.sussex.ac.uk\/jrustedlab\/wp-json\/wp\/v2\/posts\/285\/revisions"}],"predecessor-version":[{"id":294,"href":"https:\/\/blogs.sussex.ac.uk\/jrustedlab\/wp-json\/wp\/v2\/posts\/285\/revisions\/294"}],"wp:attachment":[{"href":"https:\/\/blogs.sussex.ac.uk\/jrustedlab\/wp-json\/wp\/v2\/media?parent=285"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.sussex.ac.uk\/jrustedlab\/wp-json\/wp\/v2\/categories?post=285"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.sussex.ac.uk\/jrustedlab\/wp-json\/wp\/v2\/tags?post=285"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}