Depression and Cognitive Ageing

By Amber John

Depression is a common mental health problem which is experienced by people of all ages. It is estimated that each year around 1 in 5 people in the UK will experience depressive symptoms. Depression encompasses lots of different kinds of symptoms which can range from mild to severe. This can include psychological symptoms (such as a continuous low mood, feelings of hopelessness and guilt and lacking motivation), physical symptoms (such as changes in sleeping patterns, weight and appetite changes, and loss of energy), and social symptoms (such as withdrawal from friends and family, or underperforming at school or work). For more information on recognising symptoms of depression, follow this link to the NHS website, which can describe this in more depth: https://www.nhs.uk/conditions/clinical-depression/symptoms/

There is some evidence to suggest that depression may be linked with poorer physical, mental, and cognitive outcomes later in life. For example, scientists have previously reported that experiencing depression may be related to an increased risk of stroke, diabetes and early mortality. Researchers have also previously shown a link between depression in older adulthood and dementia. However, we do not yet know whether depression can lead to a faster cognitive decline in a population of individuals without dementia. The aim of our study was to test whether there is comprehensive evidence for the effect of depression on cognitive decline in cognitively healthy older adults.

 

WHAT DID WE DO?

We conducted a systematic review and meta-analysis of longitudinal studies investigating the link between depression or anxiety and decline in cognitive function in people without dementia. In total, evidence from 34 studies and more than 71,000 participants was combined and synthesised. There were 32 studies looking at depression and cognitive decline; and 5 studies looking at anxiety and cognitive decline (Three of these studies assessed both depression and anxiety).

WHAT WE FOUND AND WHAT IT MEANS

Our results suggest that people diagnosed with clinical depression are more likely to experience a faster cognitive decline over time than people without depression (OR 1.36, 95% CI 1.05–1.76, p = 0.02). We also found that people who do not have a formal diagnosis of depression but have elevated depressive symptoms are also more likely to show greater cognitive decline than people with lower depressive symptoms (B =−0.008, 95% CI −0.015 to −0.002, p = 0.012). There was mixed evidence regarding the link between anxiety and cognitive decline. Our results highlight the importance of protecting mental health in order to safeguard against cognitive decline in later life, particularly as our populations are ageing rapidly and the number of older adults living in our society is expected to increase significantly over the next few decades. For more information about this study you can access the publication online: https://www.ncbi.nlm.nih.gov/pubmed/29792244 or see the infographic.

 

HOW TO PROTECT YOUR MENTAL HEALTH

Not everyone with depression will show faster cognitive decline. There are lots of other important factors which may play into the rate at which we age, such as genetic factors, education level, sleeping patterns, and diet. As there are so many other important factors which play a role in predicting cognitive health in older age, it is not inevitable that people with depression will experience poorer cognitive outcomes. Taking measures to manage and protect mental health and wellbeing may also help to support cognitive health in older adulthood. Some actions which can be taken to help protect mental health and wellbeing include:

  1. Practicing mindfulness meditation. Mindfulness meditation can be accessed using freely available websites and apps, such as Headspace (https://www.headspace.com).
  2. Maintaining a good work-life balance. Advice on how to stay well at work can be accessed on the following link: https://www.mind.org.uk/workplace/mental-health-at-work/taking-care-of-yourself/tips-for-employees/
  3. Maintaining social connections with others. Strong social networks with loved ones can foster important social relationships and protect against feelings of isolation and loneliness. See the following guidance for opening up to friends and family about your mental health: https://www.mind.org.uk/information-support/guides-to-support-and-services/seeking-help-for-a-mental-health-problem/talking-to-friends-family/#.Wxkp0u4vxyw

 

Also see our video below which describes a couple of practical steps that can be taken to protect mental health and wellbeing: https://www.youtube.com/watch?v=NwQq1LQZX3o&feature=youtu.be

 

SEEKING HELP FOR YOUR MENTAL HEALTH

If you think you may be experiencing symptoms of depression, anxiety or any other mental health condition, it is important to talk to your GP who will be able to offer more tailored advice for you. See online guidance from MIND, a leading mental health charity, on seeking help for a mental health problem.

https://www.mind.org.uk/information-support/guides-to-support-and-services/seeking-help-for-a-mental-health-problem/where-to-start/#.WxkScO4vxyx

If you are worried about loved one or believe they may be experiencing a mental health problem, further online support can be found through the MIND website.

https://www.mind.org.uk/information-support/helping-someone-else/

See the link below for a list of useful contacts if you need further information or support in relation to your mental health:

https://www.mind.org.uk/information-support/guides-to-support-and-services/seeking-help-for-a-mental-health-problem/useful-contacts/#.WxkqPO4vxyx

 

Amber is doing her PhD with Dr Darya Gaysina at the EDGE Lab.

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Posted in PhD research, Research

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