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The Elusive Nature of APOE ε4 in Mid-adulthood: Understanding the Cognitive Profile

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Objectives: The apolipoprotein E (APOE) ε4 allele is an established risk factor for dementia, yet this genetic variant is associated with a mixed cognitive profile across the lifespan. This study undertakes both a systematic and meta-analytic review of research investigating APOE-related differences…

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Posted in Publications, Research

The APOE paradox: do attentional control differences in mid-adulthood reflect risk of late-life cognitive decline

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Possession of an APOE e4 allele is an established risk factor for Alzheimer’s disease, while the less commonly studied e2 variant is premised to offer some protection. This research explores the purported deleterious-protective dichotomy of APOE variants on attentional control in mid-adulthood. 66 volunteers,…

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Posted in Publications, Research

How do genetic risk factors for dementia influence cognition earlier in the lifespan?

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We all age, but why do some of us age better than others? This question is especially poignant for the field of cognitive ageing, with the prevalence of dementia rising each year. At the University of Sussex, the Ageing &…

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APOE Symposium

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On May 10th, Sussex Doctoral School hosted a symposium recognising the role of Apolipoprotein (APOE) in the development and progression of Alzheimer’s disease. Carrying an APOE e4 gene is established to increase the risk of Alzheimer’s disease in older adulthood, as well as…

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